Recent studies indicate that approximately one in eight American adults has utilized GLP-1 medications, a class of drugs popular for managing chronic conditions such as diabetes and heart disease, as well as aiding in weight loss. However, a significant number—nearly 60%—of those who begin these treatments, which include Ozempic and Mounjaro for diabetes and Wegovy and Zepbound for obesity, discontinue use before completing 12 weeks, a period insufficient for achieving substantial weight reduction. This premature cessation is often due to side effects like diarrhea, vomiting, and nausea, or because individuals perceive the drugs as ineffective or are deterred by the cost, even with manufacturer assistance programs that can still run over $1,000 without insurance coverage.

Dr. Eduardo Grunvald, medical director of the weight management program at the University of California, San Diego, emphasizes the chronic nature of obesity, stating, "We refer to them as anti-obesity medications because we are addressing the chronic disease of obesity, which typically requires indefinite use of these medications." He acknowledges that while he supports individuals who wish to discontinue use, most are likely to regain weight if they stop taking the medication.

Individual experiences with these medications vary widely. Alexus Murphy, a 22-year-old content creator, paused her Zepbound injections for a few weeks and is vigilant about monitoring her weight. Prior to her breast reduction surgery, she consulted her doctor about weight loss medication to lower her BMI and minimize health risks. Over five months and 23 injections, she lost nearly 50 pounds. Alexus' journey included significant lifestyle changes, including diet and exercise, which contributed to her weight loss. Despite the positive impact on her confidence and social life, she experienced side effects such as fatigue, nausea, and brain fog.

Additionally, she battled hormonal acne and had several fainting episodes, which were attributed to low blood sugar and dehydration. Now weighing less than during her middle school years, Alexus credits her weight loss for improved mental health. She accessed Zepbound through her health insurance with Inland Empire Health Plan, a program for Medi-Cal beneficiaries in California. Despite the economic challenges, she attempted to lose the last 10 pounds naturally to avoid dependency on the medication. After achieving her goal weight, she felt she was backsliding and took another dose of Zepbound. She is now certain that this will be her final course of the medication due to the acne and other hormonal side effects. Alexus hopes her audience will continue to follow her journey, focusing on overall wellness beyond weight loss.

Steven Ray, a 37-year-old father of two, found success with compounded semaglutide, a process allowed by the FDA during shortages of commercially available drugs. He lost over 40 pounds in four months and was able to maintain his weight loss after stopping the medication. Ray's experience was relatively side effect-free, with only minor acid reflux and stomach cramping. His blood sugar, cholesterol, and testosterone levels improved, and his self-esteem soared. He attributes his maintenance of weight loss to portion control and conscious eating habits, viewing the medication as a catalyst for lifestyle changes.

Becky Bell, a 69-year-old from Georgia, had a transformative experience with Ozempic. After her husband's death, she found solace in food, leading to a significant weight gain. Her doctor prescribed Ozempic to help her lose weight and prevent her prediabetes from worsening. Although she lost 70 pounds, the side effects, including nausea, low energy, and dizziness, led her to discontinue the medication. Joining a fitness studio for adults over 50, she continued her weight loss journey and found a supportive community. Bell has lost an additional 25 pounds and feels more confident than ever. She no longer considers returning to Ozempic, valuing the exercise and self-confidence she has gained.

Dustin Gee, a 37-year-old from Massachusetts, realized the impact of his weight gain while on a trip to Peru. He had gained about 30 pounds and noticed mobility issues, prompting him to seek medical advice. With the adoption of his three sons approaching, Gee was determined to lose weight and improve his health. He started Wegovy in February 2023 and lost 30 pounds by the adoption date in May. Concerned about his blood sugar and cholesterol levels, Gee continued Wegovy and lost an additional 45 pounds by September.

He then decided to incorporate lifestyle changes, following the Mayo Clinic Diet and planning to quit the medication by February. Gee credits structure and routine for his ability to maintain his weight loss, emphasizing the importance of consistency and support from his family. He plans to continue with the Mayo Clinic Diet program as part of his sustainable lifestyle.